What should I avoid while taking Femara?

When you first start taking Femara (letrozole) you should avoid driving, operating machinery or other activities that require you to be alert, until you know how Femara will affect you. Many women experience drowsiness with this medication, so avoid these activities if you have this side effect. The drowsiness is increased by other substances that cause sedation, including alcohol, so you should keep this in mind if you use these substances.