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What side effects do Truvada and raltegravir have?

Donna Hill Howes, RN
Family Practitioner

Side effects may include anxiety, depression, fatigue, dizziness, headaches, insomnia, inflammation of the sinuses or throat, abnormal skin sensations, muscle or joint pain, cough, fever, abdominal pain, indigestion, nausea, vomiting, diarrhea, and rash. Body fat may accumulate on the upper back and abdomen, with a reduction in the face, arms, and legs.

More serious side effects include a buildup of lactic acid in the blood, an enlarged liver, severe skin reactions, and weakened bones with pain and fractures. Your immune system may begin to attack healthy cells, causing diseases such as Graves disease and Guillain-Barre syndrome. Some people have an allergic reaction to the drugs. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.