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What side effects do Truvada and ritonavir-boosted darunavir have?

Donna Hill Howes, RN
Family Practitioner

Side effects may include anxiety, depression, weakness, sleepiness, dizziness, headaches, fever, insomnia, yellowing of the skin or eyes, blurry vision, changes in your taste sensations, inflammation of the sinuses or throat, cough, flushing, abnormal skin sensations, itching, sweating, muscle or joint pain, loss of appetite, abdominal pain, indigestion, nausea, vomiting, diarrhea, and rash. Your cholesterol and triglycerides may increase substantially.

Body fat may accumulate on the upper back and abdomen, with a reduction in the face, arms, and legs. More serious side effects include a buildup of lactic acid in the blood, enlarged liver, hepatitis, inflammation of the pancreas, and weakened bones with pain and fractures. Your immune system may begin to attack healthy cells, causing diseases such as Graves disease and Guillain-Barre syndrome. Some people have a severe allergic reaction.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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