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How effective are H2 blockers?

Donna Hill Howes, RN
Family Practitioner

H2 blockers are not as effective as proton pump inhibitors. They are most effective at controlling night-time rather than meal-related reflux.

An H2 blocker can help reduce acid reflux during sleep. It can be taken at bedtime, as an add-on to a daytime PPI (proton pump inhibitor) drug.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

H2 blockers can be effective, but are not typically as effective as proton pump inhibitor (PPI) medications. They carry less risk for malabsorption issues than PPIs and are generally well tolerated. It is often advisable to start an H2 blocker for mild gastroesophageal reflux disease (GERD) symptoms prior to starting a PPI such as omeprazole.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.