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Do H2 blockers interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking any of the following drugs, cimetidine can lead to side effects and should be avoided:

  • amiodarone
  • carmustine
  • dofetilide
  • doxorubicin
  • epirubicin
  • lomitapide
  • pirfenidone
  • quinidine
  • simeprevir
  • thioridazine
  • tolvaptan
  • ulipristal

If you are taking atorvastatin, colchicine, escitalopram, a hydantoin anticonvulsant, or oxycodone, cimetidine may not be a good option for you.

If you are taking risedronate, delavirdine, posaconazole, or a tyrosine kinase inhibitor, H2 blockers can lead to side effects and should be avoided.

If you are taking pimozide, cimetidine and nizatidine can lead to side effects and should be avoided.

If you are taking a medication that prolongs the QTc interval, H2 blockers can lead to serious side effects.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.