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What is Rexulti?

Rexulti (brexpiprazole) is a drug intended to treat both schizophrenia and major depressive disorder (MDD). It is a type of drug known as an atypical antipsychotic. Rexulti is taken as a tablet, with or without food; treatment begins with a daily dose as low as .5 mg and may go as high as 4 mg. For MDD, it is typically used as an adjunct medication with a second antidepressant. Rexulti is not approved for use with pediatric patients. Patients ages 24 and under have shown increased depression and suicidal thoughts when using similar antidepressants. Elderly patients with dementia-related psychosis should not be treated with this drug, as it can cause an increased risk of death by infection or cardiovascular problems. Side effects may include weight gain, restlessness and agitation, as well as headache, dizziness, fatigue and constipation. Safety has not been established in pregnant or nursing women.

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