What are benzisoxazole derivatives?

Donna Hill Howes, RN
Family Practitioner

Benzisoxazole derivatives are second-generation (atypical) antipsychotic drugs. They work by blocking the action of dopamine and serotonin, two brain chemicals that regulate mood and behavior. They are taken by mouth or injection.

Benzisoxazole derivatives used to treat schizophrenia include iloperidone (Fanapt), paliperidone (Invega), risperidone (Risperdal), and ziprasidone (Geodon). Paliperidone (Invega Sustenna) and risperidone (Risperdal Consta) are also available in a long-acting injectable form. 

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