What are possible side effects of thiothixene?

Donna Hill Howes, RN
Family Practitioner

Thiothixene frequently affects the nervous system, and may cause muscle spasms, trouble staying still, tremors, repetitive involuntary movements, and increased salivation. Other side effects may include agitation, insomnia, dizziness, weakness, fatigue, weight gain, dry mouth, blurry vision, nasal congestion, a skin rash, itching, hives, increased sweating, leg cramps, nausea, vomiting, constipation, and erectile dysfunction in men. 

Some people have developed neuroleptic malignant syndrome. Symptoms include rigid muscles, fever, and delirium. Thiothixene can make it dangerous to drive or to operate machinery.

Older people who take antipsychotic drugs have a higher risk of death, especially from heart problems or infection. 

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