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Does lurasidone interact with any other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking lurasidone, any of the following drugs can lead to side effects and should be avoided:

  • azelastine nasal spray
  • dabrafenib
  • disopyramide
  • epinephrine
  • fusidic acid
  • idelalisib
  • conivaptan
  • orphenadrine 
  • paraldehyde
  • pimozide
  • procainamide
  • quinidine
  • thalidomide

If you are taking any of the following drugs, lurasidone may not be a good option for you:

  • a central nervous system depressant
  • lithium
  • methylphenidate
  • rufinamide
  • a serotonin reuptake inhibitor
  • tetrabenazine

If you are taking metoclopramide, lurasidone can lead to side effects and should be avoided. If you are taking another cholinesterase inhibitor, lurasidone also may not be a good option for you.

If you are taking a strong CYP3A4 inducer or a strong CYP3A4 inhibitor, you should not take lurasidone.

If you take lurasidone, you should avoid St. John's wort.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.