Advertisement

How does methotrexate treat inflammatory bowel disease?

Donna Hill Howes, RN
Family Practitioner

Methotrexate suppresses immune system activity and reduces inflammation. It was developed as a cancer treatment. But it was later found to work for other conditions in which immune system activity causes damaging inflammation, such as rheumatoid arthritis and psoriasis. When used to treat inflammatory bowel disease (IBD), it is usually given by injection. It is an alternative to the thiopurines and is used less often. It is not FDA-approved for treating IBD. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

Continue Learning about Antineoplastic Agent

What is methotrexate?
Donna Hill Howes, RNDonna Hill Howes, RN
Methotrexate (Trexall) is taken as a weekly pill or injection. It is one of the most common DMARDs (...
More Answers
Does methotrexate have any side effects?
Donna Hill Howes, RNDonna Hill Howes, RN
Side effects may include fever, headaches, drowsiness, dizziness, fatigue, blurred vision, cough, sh...
More Answers
Is it safe to take Keytruda if I am pregnant or breastfeeding?
Honor Society of Nursing (STTI)Honor Society of Nursing (STTI)
No. Keytruda (pembrolizumab) fights melanoma cancer cells by making it easier for the immune system ...
More Answers
Does rituximab interact with any other medications?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking abatacept, deferiprone, natalizumab, pimecrolimus, tacrolimus, tocilizumab, or tum...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.