Advertisement

How is methotrexate prescribed to treat inflammatory bowel disease?

Donna Hill Howes, RN
Family Practitioner

For Crohn's disease, methotrexate is most often given to people whose disease is in remission after treatment with corticosteroids. It is considered a second choice after thiopurines. It is sometimes given to people with active Crohn's disease that is not improved by corticosteroids, or those who cannot take corticosteroids. It is also sometimes given to people with active disease who have to stop taking a thiopurine because of side effects.

Methotrexate is rarely used to treat ulcerative colitis (UC) and is not recommended by current guidelines. Some small studies have not shown any benefit, but those studies used low doses or oral rather than injected methotrexate. Larger studies are currently being conducted. 

Methotrexate is used for children with Crohn's disease in similar situations as for adults. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

Continue Learning about Antineoplastic Agent

What should I know about Keytruda before taking it?
Honor Society of Nursing (STTI)Honor Society of Nursing (STTI)
Keytruda (pembrolizumab) is a drug used to treat melanoma that can't be removed surgically and isn't...
More Answers
Does mitoxantrone interact with other medications or foods?
Donna Hill Howes, RNDonna Hill Howes, RN
People taking mitoxantrone should avoid receiving live vaccines. If you are taking cyclosporine, mi...
More Answers
What should I know before taking rituximab?
Donna Hill Howes, RNDonna Hill Howes, RN
Your doctor will need to test for hepatitis B, and possibly hepatitis C, before you start treatment....
More Answers
Does rituximab interact with any other medications?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking abatacept, deferiprone, natalizumab, pimecrolimus, tacrolimus, tocilizumab, or tum...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.