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How does Gleevec treat dermatofibrosarcoma protuberans (DFSP)?

It is thought that Gleevec can help treat dermatofibrosarcoma protuberans (DFSP) by blocking the signals from an abnormal protein made by a gene called the PDGFR fusion gene. DFSP are tumors that grow under the top skin layer, and it seems that the PDGFR fusion gene makes the abnormal protein that causes cancerous cells to grow. Gleevec may work by blocking the messages from that abnormal protein that could harm the normal function of cells.

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