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How does Gleevec treat aggressive systemic mastocytosis?

The current thinking about how Gleevec treats aggressive systemic mastocytosis (AMS) is that the drug stops an abnormal protein that is made by the PDGFR (platelet-derived growth factor receptor) fusion gene or abnormal Kit gene. ASM affects the internal organs. When Gleevec stops the signals coming from the abnormal protein, healthy cell processes can continue uninterrupted and harmful cells cannot spread and impact the internal organs.

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