Does methotrexate have any side effects?

Donna Hill Howes, RN
Family Practitioner

Side effects may include fever, headaches, drowsiness, dizziness, fatigue, blurred vision, cough, shortness of breath, and chest, joint, or muscle pain. Other side effects may include bleeding of the gums, mouth, or throat, mouth sores, skin inflammation, rashes, itching, hives, abdominal pain, loss of appetite, nausea, vomiting, diarrhea, and urinary problems. Men may have erection problems. Women may have fertility problems.

Methotrexate may cause severe, potentially fatal problems, including skin reactions, liver damage, lung disease, bone marrow suppression, infections, and blood poisoning. Vaccines may not be effective when taking methotrexate. If you take methotrexate, you should avoid receiving live vaccines.

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