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Who should not take clonidine hydrochloride and chlorthalidone?

Clonidine-chlorthalidone should not be taken by anyone allergic to any of its ingredients, including thiazides such as hydrochlorothiazide, other diuretics or sulfonamide medicines, such as sulfamethoxazole. People who cannot urinate should not be treated with clonidine-chlorthalidone. This medication falls into pregnancy Category C, which means that its effects on pregnancy are not known, although animal studies may have indicated adverse effects.  Clonidine-chlorthalidone can be passed through breast milk to a nursing infant, so breastfeeding should be stopped if the medication cannot. Because the effects of this medication have not been studied on children, it should be avoided. The doctor will use extreme caution in prescribing it to people who have medical conditions, such as kidney or liver disease.

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