What drugs may interact with clonidine-chlorthalidone?

Clonidine-chlorthalidone (brand name: Clorpres) combines two medications that affect blood pressure. Clonidine helps relax blood vessels to lower blood pressure; chlorthalidone stimulates the production of urine to decrease edema, swelling from water retention. Because of this, there are many medications that may interact with Clorpres. It is crucial that you inform your doctor before treatment if you are taking any of the following medications:

  • antidepressants, such as amitriptyline, amoxapine, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, or trimipramine; beta-blockers such as propranolol
  • barbiturates and other sedatives
  • calcium channel blockers
  • corticosteroids such as cortisone
  • diabetes medications such as insulin
  • other blood pressure medications such as diazoxide
  • digitalis glycosides
  • ketanserin
  • lithium
  • narcotics such as codeine

Clonidine-chlorthalidone treatment may also interact with medications that are not on this list. Because of this, it is important to tell your doctor about any additional prescription or over-the-counter drugs, herbal or dietary supplements, vitamins or minerals that you take. Mention if you consume alcohol, smoke or use any illegal drugs, as these may decrease the safety or efficiency of your treatment. Ask your doctor if you will need to make any special changes in diet during your treatment. If you need to start taking another medication during your treatment, consult with your doctor first.

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