What drugs may interact with beta blockers?

Numerous drugs may interact with beta blockers and cause serious side effects and medical problems. Following are several examples of drugs that may interact with beta blockers:

  • nonsteroidal anti-inflammatory drugs (NSAIDs)
  • aspirin
  • insulin
  • methyldopa
  • calcium channel blockers
  • some antidepressants
  • digoxin
  • narcotics
Donna Hill Howes, RN
Family Practitioner

The following drugs can lead to serious side effects with beta blockers and should not be taken while undergoing therapy with beta blockers:

  • amiodarone
  • calcium channel blockers

The following drugs can lead to side effects if taken with beta blockers and should be avoided:

  • abiraterone
  • beta-2 adrenergic agonists
  • rivastigmine
  • tyrosine kinase inhibitors

The following drugs may interact with propranolol and should be avoided:

  • doxorubicin
  • pomalidomide
  • silodosin
  • tizanidine
  • topotecan
  • vincristine

If you are taking a CYP2D6 inhibitor, metoprolol may not be a good option for you. 

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