How does Adalat CC (nifedipine) interact with other medications or foods?

Certain drugs can decrease the effectiveness of Adalat CC (nifedipine), including seizure medications like phenytoin, phenobarbital and carbamazepine, tuberculosis drugs like rifampin, rifapentin and rifabutin and herbal medications like St. John's Wort. If you take any of these medications, your doctor may alter your dose or prescribe an alternative to Adalat CC.

Medications that can increase the side effects of Adalat CC include: quinidine and other blood pressure-lowering drugs, ketoconazole, itraconazole, fluconazole, cimetidine, protease inhibitors, nefazodone, fluoxetine, valproic acid and antibiotics such as quinupristin, dalfopristin and erythromycin. If you take these drugs, your doctor should monitor you closely while you take the drug.

Adalat CC may increase the side effects caused by other blood pressure medications, particularly beta-blockers, other calcium channel blockers, digoxin, tacrolimus and possibly certain medications used to treat diabetes, such as metformin and acarbose. If you take these drugs, your doctor should monitor you closely while you're taking Adalat CC.

Do not combine alcohol and Adalat CC, as alcohol can increase the risk of side effects, such as severely low blood pressure and decreased alertness.

Do not drink grapefruit juice or eat grapefruit while taking Aldalat CC, as grapefruit can increase the level of Adalat CC in your blood, putting you at risk of side effects such as severely low blood pressure.

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