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What are cholinergic agonists?

Donna Hill Howes, RN
Family Practitioner

Cholinergic agonist medications stimulate the involuntary nervous system. This helps the lacrimal glands make more tears, along with other effects. Two oral drugs, pilocarpine (Salagen) and cevimeline (Evoxac), are FDA-approved for dry mouth in people with Sjogren syndrome. They are not approved for dry eye in people without Sjogren syndrome. But they are often prescribed to people who have moderate or severe dry eyes due to a lack of tears (aqueous-deficient). 

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