How does timolol maleate ophthalmic solution react with other medications?

Timolol maleate ophthalmic solution (Timoptic) interacts with a variety of drugs to cause serious side effects. For example, dangerously low blood pressure or slow heart rate can occur when timolol is taken in combination with beta-blockers -- such as carvedilol (Coreg), metoprolol (Lopressor), atenolol (Tenormin), propranolol (Inderal), and sotalol (Betapace) -- or calcium channel blockers -- such as amlodipine (Norvasc), diltiazem (Cardizem), nifedipine (Procardia), verapamil (Calan).

Also, the combination of timolol and methacholine could cause a life-threatening asthma-like syndrome that is difficult to treat.

And medications known as CYP2D6 inhibitors -- chlorpromazine (Thorazine), fluoxetine (Prozac), cocaine, paroxetine (Paxil), terbinafine (Lamisil), miconazole, quinine, quinidine -- can increase your risk of experiencing side effects from timolol.

Tell your doctor about all prescription and over-the-counter (OTC) medications you take.    

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