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How does timolol maleate ophthalmic solution react with other medications?

Timolol maleate ophthalmic solution (Timoptic) interacts with a variety of drugs to cause serious side effects. For example, dangerously low blood pressure or slow heart rate can occur when timolol is taken in combination with beta-blockers -- such as carvedilol (Coreg), metoprolol (Lopressor), atenolol (Tenormin), propranolol (Inderal), and sotalol (Betapace) -- or calcium channel blockers -- such as amlodipine (Norvasc), diltiazem (Cardizem), nifedipine (Procardia), verapamil (Calan).

Also, the combination of timolol and methacholine could cause a life-threatening asthma-like syndrome that is difficult to treat.

And medications known as CYP2D6 inhibitors -- chlorpromazine (Thorazine), fluoxetine (Prozac), cocaine, paroxetine (Paxil), terbinafine (Lamisil), miconazole, quinine, quinidine -- can increase your risk of experiencing side effects from timolol.

Tell your doctor about all prescription and over-the-counter (OTC) medications you take.    

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.