Does itraconazole oral solution interact with other medications or foods?

Itraconazole oral solution may interact with other drugs. You should not take itraconazole oral solution if you are taking methadone, disopyramide, dofetilide, dronedarone, quinidine, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ranolazine, eplerenone, cisapride, lovastatin, simvastatin or colchicine, as this may cause serious complications.
Before you take itraconazole oral solution, tell your doctor if you are taking alfentanil, amiodarone, certain antibiotics, antidepressants, other antifungal azoles, barbiturates, blood thinners, buspirone, calcium channel blockers, cancer medicines, cholesterol drugs, cilostazol, cyclosporine, oral diabetes medications, digoxin, drugs that affect the body's liver enzymes, fentanyl, certain glucocorticosteroids, halofantrine, heart or blood pressure medications, medicines used to treat HIV/AIDS, isoniazid, repaglinide, rifabutin, rifampin, rifapentine, sedatives, seizure medicines, sexual dysfunction drugs for males, sirolimus, or solifenacin. Itraconazole oral solution may increase the severity of the side effects from these medications.
Before taking itraconazole oral solution, tell your doctor if you are taking any prescription or over-the-counter medications, vitamins, or herbs. Do not take any antacids or stomach-acid reducers such as Pepcid, Zantac, Nexium or Prilosec, one hour before or two hours after taking itraconazole oral solution. Itraconazole capsules require an acidic environment in the stomach for optimal absorption.

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