How does ondansetron hydrochloride interact with other medications or food?

Ondansetron hydrochloride may interact with phenytoin (Dilantin), carbamazepine (Tegretol, Carbatrol), phenobarbital (Luminal), tramadol (Ultram), or rifampin (Rimactane, Rifater, Rifadin). The drug should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. The following medications may be taken with ondansetron hydrochloride, but dosages may need adjusting: amiodarone, acecainide, arsenic trioxide, bretylium, azimilide, dofetilide, enflurane, droperidol, halothane, isoflurane, ibutilide, isradipine, sotalol, sematilide, telithromycin, tedisamil. If you have allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), or palnosetron (Aloxi), it may mean that you are also allergic to ondansetron hydrochloride. When ondansetron is taken with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Be sure to provide your doctor with a list of all medications you are taking, including prescription, non-prescription, nutritional supplements, vitamins, and herbal products.

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