Do ondansetron hydrochloride injections interact with other drugs?

Ondansetron hydrochloride Injection may interact with phenytoin (Dilantin), carbamazepine (Tegretol, Carbatrol), phenobarbital (Luminal), tramadol (Ultram), or rifampin (Rimactane, Rifater, Rifadin). The drug should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. The following medications may be taken with Ondansetron hydrochloride, but dosages may need adjusting: amiodarone, acecainide, arsenic trioxide, bretylium, azimilide, dofetilide, enflurane, droperidol, halothane, isoflurane, ibutilide, isradipine, sotalol, sematilide, telithromycin, and tedisamil.  People with allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), and palnosetron (Aloxi) may also be allergic to ondansetron hydrochloride. When ondansetron is taken with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. 

Continue Learning about Antiemetic

Could I be allergic to Vistaril?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Allergy symptoms are triggered by the release of a natural compound called histamine. Histamine star...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.