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Who should not take ondansetron hydrochloride injections?

Ondansetron hydrochloride injection should not be taken if you are allergic to dolasetron (Anzemet), palonosetron (Aloxi), or granisetron (Kytril). Tell your doctor if you have phenylketonuria, because ondansetron hydrochloride contains the amino acid phenylalanine. Tell your doctor if you are pregnant, may become pregnant, or breastfeeding. This medication is a pregnancy category B medication, which means it has not been tested in pregnant women, but does not appear to harm the fetus in animal studies. It remains unclear if ondansetron hydrochloride can be passed from the mother to the infant in breast milk. Talk to your doctor about the risks and benefits of taking this medication. There are limited studies of ondansetron hydrochloride in children six months or older for cancer treatment and one month to 12 years for post-surgery side effects. Although studies are limited, children do not appear to suffer from side effects any differently than adults. This medication has also not been extensively studied in older populations, but it also does not appear to cause different side effects. Ondansetron hydrochloride injection should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. The following medications may be taken with ondansetron hydrochloride, but dosages may need adjusting: amiodarone, acecainide, arsenic trioxide, bretylium, azimilide, dofetilide, enflurane, droperidol, halothane, isoflurane, ibutilide, isradipine, sotalol, sematilide, telithromycin, and tedisamil. Medications to treat some ailments could interact with ondansetron hydrochloride. Tell your doctor if you recently underwent abdominal surgery. Ondansetron hydrochloride could mask stomach problems. People with allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), or palnosetron (Aloxi) may also be allergic to ondansetron hydrochloride. A person with liver disease may have an increased risk of side effects when taking ondansetron hydrochloride.

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