What should I know about Aloxi before taking it?

Before taking Aloxi (palonosetron), you should know that it interacts with many medications. For example, when taken with apomorphine,  Aloxi can cause an unsafe drop in blood pressure that can result in fainting. Taking Aloxi with other drugs that increase serotonin in the brain, such as antidepressants and migraine medications, can lead to a dangerous condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Taking Aloxi along with water pills (diuretics) or heart rhythm drugs (including, amiodarone, bepridil, disopyramide, sotalol) may also pose problems. Tell your doctor about all prescription and over-the-counter (OTC) drugs and supplements you take before starting treatment. If you are pregnant or may become pregnant talk to your doctor about taking Aloxi. Also, do not take this drug if you are allergic to palonosetron, the main ingredient in Aloxi, or to similar medications such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril, Sancuso), ondansetron (Zofran). Aloxi may also worsen several medical conditions, and people who have a history of heart conditions or low blood levels of magnesium and potassium should avoid this medication. Aloxi can cause severe allergic reactions, so get help immediately if you have symptoms such as a rash, hives, or swelling. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.