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How does aprepitant work?

Certain centers in your brain sense chemicals in your blood and control the feelings of nausea and vomiting. They do so by producing a chemical called substance P. Substance P makes you feel nauseated and stimulates the nerves to your stomach that cause vomiting. Aprepitant (Emend) binds to the surfaces of nerve cells in your brain and nerves that control nausea and vomiting. It prevents substance P from working, thereby preventing feelings of nausea and vomiting.

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