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Are there any risks in taking Aloxi?

Aloxi (palonosetron) interacts with many medications. For example, when taken with apomorphine Aloxi can cause an unsafe drop in blood pressure that can result in fainting. Taking Aloxi along with water pills (diuretics) or heart rhythm drugs (including, amiodarone, bepridil, disopyramide, sotalol) may also pose problems. Taking Aloxi with other drugs that increase serotonin in the brain, such as antidepressants and migraine medications, can lead to a dangerous condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Tell your doctor about all prescription and over-the-counter (OTC) drugs and supplements you take before starting treatment. Aloxi may also worsen several medical conditions, and people who have a history of heart conditions or low blood levels of magnesium and potassium should avoid this medication. Aloxi can cause dizziness or drowsiness, so avoid alcohol after getting an injection of Aloxi because alcohol may enhance these side effects. Also, because Aloxi may make you less alert do not drive or use machinery after the drug until you know whether you will be affected. Aloxi may pass into breast milk, so let your doctor know if you are nursing. Aloxi can cause severe allergic reactions, so get medical help immediately if you have symptoms such as a rash, hives, or swelling. 

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