Emend (aprepitant) is a typically a three-day regimen to help prevent nausea and vomiting associated with chemotherapy. Typically, the first day the patient receives a 125 mg tablet and the next two days they receive 80 mg doses.
Antiemetic
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Stacy Wiegman, PharmD , Pharmacy, answeredCommon side effects of prochlorperazine include nervousness, sleeplessness, sleepiness, dizziness, blurry vision, stuffy nose, constipation, and chills. Some people experience more extreme side effects that should be reported immediately to a doctor. These include:- changes in mental ability, vision or eye movements, breasts, menstruation, erections, or heartbeat;
- yellowing of the eyes or skin;
- becoming extremely agitated;
- problems with muscles, such as lack of control, spasms or stiffness, or weakness;
- fever and/or feeling hot with sweat;
- symptoms of allergic reaction, such as hives, itching, trouble breathing, or swelling of the mouth or tongue.
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Stacy Wiegman, PharmD , Pharmacy, answeredZofran (ondansetron) prevents nausea by blocking specific receptors for the brain chemical serotonin and can be dangerous to take with certain other medications, especially if they also affect the brain and nervous system. These include medications for seizures, insomnia, anxiety, depression, migraines, pain, bipolar disorder, and even certain antibiotics prescribed to treat an infection. Make sure your doctor is aware you are taking the following medications before taking Zofran: apomorphine, phenytoin, carbamazepine, rifampicin, and tramadol. Zofran (ondansetron) may interact with over-the-counter medications for colds and allergies, pain, anxiety, and insomnia. Talk with your doctor about all medications that you are taking, including dietary supplements, before you take Zofran (ondansetron).
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Stacy Wiegman, PharmD , Pharmacy, answeredBefore taking Aloxi (palonosetron), you should know that it interacts with many medications. For example, when taken with apomorphine, Aloxi can cause an unsafe drop in blood pressure that can result in fainting. Taking Aloxi with other drugs that increase serotonin in the brain, such as antidepressants and migraine medications, can lead to a dangerous condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Taking Aloxi along with water pills (diuretics) or heart rhythm drugs (including, amiodarone, bepridil, disopyramide, sotalol) may also pose problems. Tell your doctor about all prescription and over-the-counter (OTC) drugs and supplements you take before starting treatment. If you are pregnant or may become pregnant talk to your doctor about taking Aloxi. Also, do not take this drug if you are allergic to palonosetron, the main ingredient in Aloxi, or to similar medications such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril, Sancuso), ondansetron (Zofran). Aloxi may also worsen several medical conditions, and people who have a history of heart conditions or low blood levels of magnesium and potassium should avoid this medication. Aloxi can cause severe allergic reactions, so get help immediately if you have symptoms such as a rash, hives, or swelling.
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Stacy Wiegman, PharmD , Pharmacy, answeredAloxi (palonosetron) interacts with many medications. For example, when taken with apomorphine Aloxi can cause an unsafe drop in blood pressure that can result in fainting. Taking Aloxi along with water pills (diuretics) or heart rhythm drugs (including, amiodarone, bepridil, disopyramide, sotalol) may also pose problems. Taking Aloxi with other drugs that increase serotonin in the brain, such as antidepressants and migraine medications, can lead to a dangerous condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Tell your doctor about all prescription and over-the-counter (OTC) drugs and supplements you take before starting treatment. Aloxi may also worsen several medical conditions, and people who have a history of heart conditions or low blood levels of magnesium and potassium should avoid this medication. Aloxi can cause dizziness or drowsiness, so avoid alcohol after getting an injection of Aloxi because alcohol may enhance these side effects. Also, because Aloxi may make you less alert do not drive or use machinery after the drug until you know whether you will be affected. Aloxi may pass into breast milk, so let your doctor know if you are nursing. Aloxi can cause severe allergic reactions, so get medical help immediately if you have symptoms such as a rash, hives, or swelling.
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Stacy Wiegman, PharmD , Pharmacy, answeredOndansetron hydrochloride Injection may interact with phenytoin (Dilantin), carbamazepine (Tegretol, Carbatrol), phenobarbital (Luminal), tramadol (Ultram), or rifampin (Rimactane, Rifater, Rifadin). The drug should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. The following medications may be taken with Ondansetron hydrochloride, but dosages may need adjusting: amiodarone, acecainide, arsenic trioxide, bretylium, azimilide, dofetilide, enflurane, droperidol, halothane, isoflurane, ibutilide, isradipine, sotalol, sematilide, telithromycin, and tedisamil. People with allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), and palnosetron (Aloxi) may also be allergic to ondansetron hydrochloride. When ondansetron is taken with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting.
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Stacy Wiegman, PharmD , Pharmacy, answeredOndansetron hydrochloride may interact with phenytoin (Dilantin), carbamazepine (Tegretol, Carbatrol), phenobarbital (Luminal), tramadol (Ultram), or rifampin (Rimactane, Rifater, Rifadin). The drug should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. The following medications may be taken with ondansetron hydrochloride, but dosages may need adjusting: amiodarone, acecainide, arsenic trioxide, bretylium, azimilide, dofetilide, enflurane, droperidol, halothane, isoflurane, ibutilide, isradipine, sotalol, sematilide, telithromycin, tedisamil. If you have allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), or palnosetron (Aloxi), it may mean that you are also allergic to ondansetron hydrochloride. When ondansetron is taken with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. Be sure to provide your doctor with a list of all medications you are taking, including prescription, non-prescription, nutritional supplements, vitamins, and herbal products.
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Stacy Wiegman, PharmD , Pharmacy, answeredBefore beginning ondansetron hydrochloride treatment, talk to your doctor about all allergies, especially if you have an allergy to medications like dolasetron (Anzemet), palonosetron (Aloxi), or granisetron (Kytril). Tell your doctor if you have the disorder phenylketonuria or long QT syndrome, if you are pregnant, may become pregnant, or breastfeeding. This medication has not been extensively tested in pregnant women, and it remains unclear if the medication can be passed from mother to infant through breast milk. Talk to your doctor about risks and benefits of using this medication. If ondansetron is used with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting.
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Stacy Wiegman, PharmD , Pharmacy, answeredYes, you should always check with your pharmacist about taking any new medications. Zofran (ondansetron) can be dangerous if you are also taking certain medications, such as those for Parkinson’s, heart problems, seizures, insomnia, anxiety, depression, migraines, pain and bipolar disorder. It may also have a negative interaction with certain antibiotics. Tell your pharmacist about all your prescription and over-the-counter medications, as well as any dietary supplements you are taking.