What are the side effects of diphenoxylate and atropine?

Diphenoxylate and atropine can cause several side effects. Some of the most common, but least concerning, side effects include: headaches, blurred vision, constipation, sweating, dry mouth or skin, drowsiness, dizziness, restlessness, skin rash, itchiness, loss of appetite or taste and digestive upset.

If you feel confused, have a faster than normal or irregular heartbeat, hallucinate, feel numbness in your extremities, become depressed or agitated, you should contact your doctor. Also, if your pupils enlarge severely, if you have difficulty focusing your eyes or urinating, if you get unduly excited, if diarrhea gets worse, if blood appears in the stools, if you feel bloated or if you have stomach pain while taking diphenoxylate and atropine, let your physician know immediately.

You should also watch for signs of dehydration, including not urinating as much or at all, excessive thirst, dry mouth, muscle cramps and lethargy.

In rare cases, you may have an allergic reaction to the drug. Call your healthcare provider immediately if you have trouble breathing or develop an itchy rash, hives or swelling in your face and throat.

Based on information from, a free medication monitoring service, 20% of patients experience side effects while taking Diphenoxylate with Atropine (Lomotil). Some of the side effects reported by iGuard members include:

  • Constipation
  • Dryness
  • Drowsiness
  • Restlessness
  • Anxiety
  • Swelling/Edema
  • Headache
Please follow up with your doctor or other healthcare provider if you are experiencing any symptoms that worsen or do not go away.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.