Children under two years of age should not take difenoxin and atropine. This drug should be used with caution in older children and persons with Down's syndrome, because they may be more susceptible to side effects, such as high fever, fast heartbeat, decreased urination, flushing, dry skin, dry mouth or thirst.
Motofen should only be used by pregnant or breastfeeding women with extreme caution. Motofen can be passed to a nursing infant through breast milk.
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