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How can I minimize the side effects of Pylera?

You can minimize side effects from Pylera, a medication used to treat peptic ulcers, by telling your doctor about all your medications or supplements, because some may interact with the treatment. Drugs that may interact with Pylera include:
  • disulfiram (Antabuse)
  • penicillin
  • certain anticoagulants such as warfarin (Coumadin, Jantoven)
  • cimetidine (Tagamet)
  • lithium (Eskalith, Lithobid)
  • phenobarbital (Luminal)
  • phenytoin (Dilantin, Phenytek)
  • probenecid (Col-probenecid, Probalan)
  • sulfinpyrazone
  • diabetes medications
If you take antacids containing aluminum, calcium, magnesium or sodium bicarbonate, or a zinc supplement, take them one to two hours before or one to two hours after a dose of Pylera. Foods that contain calcium should be eaten at least two hours before or one hour after a dose of Pylera. Iron supplements should be taken at least three hours before or two hours after.

You can also minimize side effects by avoiding beverages and products with alcohol or propylene glycol while you're taking Pylera and for at least three days after you finish the therapy. Alcohol and propylene glycol can cause nausea, vomiting, stomach cramps, headache, sweating and redness of the face when taken with metronidazole, one of the antibiotics used in Pylera.

Tell your doctor if you are allergic to bismuth, metronidazole or tetracycline, the three main ingredients in Pylera. Also tell your doctor if you are allergic to doxycycline (Doryx, Vibramycin), minocycline (Dynacin, Minocin) or tinidazole (Tindamax). Tell your doctor if you have kidney or liver disease, an infection, Crohn's disease, a central nervous system condition, or if you have ever had blood problems.

Pylera can decrease the effectiveness of hormonal contraceptives such as birth control pills, so use another form of birth control to reduce your risk of pregnancy. Pylera can also make your skin sensitive to ultraviolet light, so you should avoid prolonged sun exposure, tanning beds and sun lamps while you're taking it, and  wear protective clothing and sunscreen.

Take each dose, especially the bedtime dose, with eight ounces of water to help prevent stomach irritation. Even with these precautions, Pylera may cause temporary, harmless side effects such as darkening of your tongue and of your stool. Talk to your doctor if you experience symptoms that bother you or don't go away.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.