What are the side effects of Symlin (pramlintide acetate)?

Some side effects of using Symlin (pramlintide acetate) are:
  • Low blood sugar. Symlin is used with insulin to lower blood sugar, but blood sugar may drop too low, particularly if you have type 1 diabetes. When first starting Symlin, doses of insulin must be reduced before meals as recommended by a doctor to reduce the chances of low blood sugar.
  • Nausea. Nausea is the most common side effect of using Symlin.
  • Other side effects. Possible side effects include decreased appetite, vomiting, stomach pains, exhaustion, dizziness or indigestion. Symlin can also cause reactions at the injection site, including redness, minor bruising or pain.
Symlin should be used exactly as prescribed. People should work with their medical team to help integrate Symlin into their diabetes management plan.
Some people may have an allergic reaction to Symlin, causing symptoms such as hives, swelling in your face or throat, and difficulty breathing. If you experience these symptoms, seek medical attention by calling 911. Symlin may also increase your risk of dangerously low blood sugar (hypoglycemia), especially in people with type 1 diabetes. Symptoms of low blood sugar may include sweating, headache, hunger, irritability, difficulty concentrating, and tremor. If left untreated, hypoglycemia can lead to more serious side effects, such as seizure, loss of consciousness, and coma. To reduce the risk of developing hypoglycemia, talk to your doctor about a plan for dealing with low blood sugar, including having a source of fast-acting sugar on hand at all times. Other side effects of Symlin may include nausea, stomach pain, decreased appetite, indigestion, vomiting, tiredness, dizziness, muscle pain, and headache. You may also develop irritation or redness in the area where you inject Symlin. If you experience any side effects while taking Symlin, talk to your doctor right away.

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