What are possible side effects of Glucovance?

The most common side effects of Glucovance (glyburide and metformin), a combination drug for type 2 diabetes, include diarrhea, headache, upper respiratory infection, nausea or vomiting, abdominal pain and dizziness. In clinical trials, each of these symptoms occurred more than 5% of the time. Rare but more serious side effects include those caused by low blood sugar (hypoglycemia). Signs of low blood sugar include:
  • dizziness
  • shakiness
  • sweating
  • hunger
  • seizure
  • coma
Like many other diabetes medications, Glucovance can cause hypoglycemia, or low blood sugar. Hypoglycemia can be dangerous, leading to confusion, seizures or loss of consciousness. Earlier signs include:
  • light-headedness
  • dizziness
  • shakiness
  • sweating
  • nervousness
  • irritability
  • weakness
Rarely, Glucovance can also cause a serious condition known as lactic acidosis. Call your doctor right away if you have symptoms of lactic acidosis, including:
  • general uneasiness or discomfort
  • trouble breathing
  • muscle pain
  • sleepiness
  • stomach pain or discomfort
  • high blood pressure
  • feeling cold
  • irregular heartbeat

Continue Learning about Antidiabetic

Do alpha-glucosidase inhibitors have any drug interactions?
Donna Hill Howes, RNDonna Hill Howes, RN
Drugs that may cause hyperglycemia or hypoglycemia need to be administered with caution to prevent l...
More Answers
What is rosiglitazone (Avandia) and is it safe to treat diabetes?
Diana MeeksDiana Meeks
Avandia improves how insulin is used in your body. It also decreases the amount of sugar released by...
More Answers
What are thiazolidinediones?
American Diabetes AssociationAmerican Diabetes Association
Rosiglitazone (Avandia) and pioglitazone (ACTOS) are in a group of drugs called thiazolidinediones. ...
More Answers
Do sulfonylureas interact with any other medications?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking bosentan, you should not take glyburide and avoid tolbutamide if possible. If you...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.