What drugs interact with chlorpropamide?

Chlorpropamide (Diabinese) interacts with a variety of medications to increase risk of developing low blood sugar, reduce the effectiveness of chlorpropamide, or increase the severity of side effects.

Medications that can cause low blood sugar when taken with chlorpropamide include: beta-blockers; urinary acidifiers; ACE inhibitors; sulfonamides; anticoagulants; salicylates; azole antifungals; some antibiotics; chloramphenicol; probenicid; clofibrate; phenylbutazone; nonsteroid anti-inflammatories; MAO inhibitors; and insulin. The combination of gemfibrozil and chlorpropamide may increase or decrease blood sugar if used with chlorpropamide.

The effectiveness of chlorpropamide is reduced when it is taken with thyroid medications; calcium channel blockers; sympathomimetics; corticosteroids; rifamycins; decongestants; phenytoin; diazoxide; niacin; diuretics; isoniazid; birth control pills, and estrogen.

Finally, barbiturates can increase the severity of side effects caused by chlorpropamide.

Tell your doctor all prescription and over-the-counter (OTC) medications you are taking.

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