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What should I avoid while taking repaglinide and metformin?

The most important thing to avoid while taking repaglinide and metformin (PrandiMet) is drinking a lot of alcohol or drinking alcohol too often. The metformin in this combination drug, which is used to treat type 2 diabetes, can accumulate in the body when there's alcohol present and lead to a serious condition called lactic acidosis. Lactic acidosis causes nausea and weakness and likely requires hospitalization. If your doctor prescribes repaglinide and metformin for type 2 diabetes, discuss how much alcohol is safe for you to drink while you're taking this medication.

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