Does intermediate-acting insulin interact with other medications or foods?

When combined with certain medications, intermediate-acting insulin may cause life-threateningly low blood sugar levels. Some of these medications include: beta blockers, such as propanolol, atenolol and others; angiotensin-converting enzyme (ACE) inhibitors, such as ramipril, quinapril, enalapril and others; Norpace, Norpace CR; fibrates, such as gemfibrozil, fenofibrate and others; reserpine; octreotide; salicylates, such as aspirin, Trilisate, diflunisal and others; oral diabetes medications; monoamine oxidase inhibitors (MAOIs), such as Azilect, Marplan, phenelzine (Nardil), selegiline and others; and sulfonamides, such as Fansidar, sulfadiazine, Septra, Bactrim and others. Because so many medications can affect your blood sugar, including many medications that can raise your blood sugar, you should always consult with your doctor prior to starting any new medications. In some cases, dose adjustment of your insulin may be all that's required. In other cases, another medication that doesn't interact with insulin may be an option.

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