How common is lactic acidosis in people taking glyburide and metformin?

The potentially life-threatening adverse reaction known as lactic acidosis is rare among people taking glyburide and metformin (brand name: Glucovance). It occurs in one out of more than 30,000 people taking metformin, but it is fatal in roughly half of all cases.

To minimize the risk of this condition, have your kidney and liver function tested before you start glyburide and metformin (especially if you are a senior), and avoid this drug if you drink large amounts of alcohol.