How does glipizide-metformin interact with other medications and food?

Certain medications and foods may interact to glipizide-metformin.

Some medications should never be used while taking glipizide-metformin, such as radiopaque contrast agents (ioglycamic acid, ioglicic acid, iohexol, iopamidol, iomeprol, iopanoic acid, iophendylate, iopentol, iopromide, ioseric acid, iopronic acid, iosimide, iothalamate, iotasul, iotrolan, ioversol, iotroxic acid, ioxalgate, ipodate, ioxitalamic acid, metrizamide, diatrizoate, acetrizoic acid, ethiodized oil, iobitridol, iobenzamic acid, iocarmic acid, dofetilide, iocetamic acid, gatifloxacin, iodipamide, iodamide, iodixanol, metrizoic acid, iodopyracet acid, iodohippuric acid, idoxamic acid, and tyropanoate sodium), dofetilide, and gatifloxacin.

Other medications that may interact with glipizide-metformin include methotrexate, aspirin, chloramphenicol, clarithromycin, digoxin, diuretics, female hormones and birth control pills, isoniazid, blood pressure, heart disease, and irregular heart beat medications, fungal infection medications, MAO inhibitors, morphine, niacin, NSAIDs, phenothiazines, phenytoin, probenecid, procainamide, quinidine, ranitidine, steroid medicines, stimulant medicines, thyroid medicines, trimethoprim, vancomycin, and warfarin.

Other medications might also interact adversely with glipizide-metformin. Talk to your doctor about any medication you are taking to ensure that it does not interfere with glipizide-metformin.

Alcohol and tobacco should also be avoided.

Since glipizide-metformin lowers your blood sugar levels, it can sometimes result in blood sugar levels that are too low, or hypoglycemia. In order to avoid a hypoglycemic episode, you should try to avoid stress and alcohol as well as eat regular meals. If your glucose levels drop too low and you suffer from a hypoglycemic episode there are several things you can do to bring it back up. This includes consuming a sugar source like orange juice, milk, candy, or glucose gel or using an injection of glucagon.

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