How common is lactic acidosis in people taking Glucovance?

Lactic acidosis is an extremely rare but often fatal reaction to Glucovance (glyburide and metformin), a combination of two drugs that treats type 2 diabetes. It occurs in one out of more than 30,000 people taking the medication. However, when it does develop, it is fatal in half the cases.

To minimize your risk for developing this dangerous condition, have your kidney function tested before you start taking Glucovance (especially if you are a senior). Make sure your liver is healthy, too, and talk to your doctor about any heart problems because some can increase your risk. Don't take this drug if you drink alcohol in excess.

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