Advertisement

How does Avandamet cause lactic acidosis?

Metformin, one of the two main active ingredients in Avandamet, has been associated with lactic acidosis, which is a harmful buildup of lactic acid (a normal product of muscle metabolism) in the body. Lactic acidosis occurs when the cells of the body produce acid faster than it can be metabolized. Thus, the liver cannot convert this lactate buildup into glucose in a normal way.
Lactic acidosis is associated with liver and kidney damage and this condition can be fatal. Get immediate medical attention if you have any symptoms of lactic acidosis, including: diarrhea, difficulty breathing, dizziness, extreme weakness or fatigue, shallow breathing, loss of appetite, muscle cramps, numb or cold feeling in your arms and legs, slow or erratic heartbeat, stomach pain, unusual drowsiness, and vomiting. Your risk of developing lactic acidosis is increased if you take too much Avandamet or if you drink alcohol while taking this drug. Other health conditions (particularly pre-existing liver or kidney disease) may also increase your risk.

Continue Learning about Antidiabetic

If I need insulin to control my blood glucose, which type should I take?
American Diabetes AssociationAmerican Diabetes Association
Your insulin doses should mimic how insulin works naturally in the body. In people without diabetes,...
More Answers
What is Novolin?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Novolin (insulin human) is a form of man-made insulin -- a hormone normally produced in the panc...
More Answers
What are alpha-glucosidase inhibitors?
Donna Hill Howes, RNDonna Hill Howes, RN
Alpha-glucosidase inhibitors slow the digestion of carbohydrates in the small intestine. Alpha-gluco...
More Answers
How do meglitinide drugs help treat diabetes?
Dr. Jack Merendino, MDDr. Jack Merendino, MD
The meglitinides Prandin and Starlix prompt the body to make more insulin. They are fast-acting and ...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.