Advertisement

What is the difference between Glyburide and Glipizide?

William Lee Dubois
Endocrinology Diabetes & Metabolism
Both of these medications belong to the same class of drugs, called sulfonylureas. They work by causing the pancreas to produce (or some would argue, over-produce) insulin. The medications are cheap and can be very effective for a few years, but are falling out of favor as they can cause weight gain, already a problem for most Type-2s; carry a risk of low blood sugar; and because they may “burn out” the pancreas, making you dependent on insulin sooner than you naturally would be.

Recent research shows that by the time someone is diagnosed with Type-2 diabetes, their insulin producing capacity is already reduced to around 65%, because the body has been trying to compensate for increasing insulin resistance for years. Sulfonylureas hasten this degradation.

The main difference between the two medications is in how quickly they start working and how long they remain effective. The more common glipizide (brand name Glucotrol) peaks in 1-3 hours and generally lasts 12 hours in most people. Glyburide (brand names Micronase and DiaBeta) peaks later, usually in four hours, and stays active in the body for 24 hours. Interestingly, Glyburide has been shown to be an especially helpful medication for diabetic cats, but doesn’t seem to help with dogs who have diabetes. Go figure.

Continue Learning about Antidiabetic

How do the diabetes drugs Byetta and Victoza affect weight?
Dr. Jack Merendino, MDDr. Jack Merendino, MD
Since it was introduced in 2006, Byetta has been prescribed widely. Victoza was introduced in 2010 a...
More Answers
Do any other drugs interact with pramlintide?
Donna Hill Howes, RNDonna Hill Howes, RN
Because pramlintide may affect absorption rates of some oral drugs, follow instructions carefully fo...
More Answers
What is Symlin (pramlintide acetate) for diabetes?
American Diabetes AssociationAmerican Diabetes Association
Pramlintide (brand name Symlin) is a synthetic form of the hormone amylin, which is produced along w...
More Answers
Do alpha-glucosidase inhibitors have any drug interactions?
Donna Hill Howes, RNDonna Hill Howes, RN
Drugs that may cause hyperglycemia or hypoglycemia need to be administered with caution to prevent l...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.