Can glyburide and metformin interact with other medications or foods?

Glyburide and metformin (brand name: Glucovance), a combination medication for type 2 diabetes, can interact with many other drugs. Some affect how well the glyburide and metformin combo works; in other cases, glyburide and metformin may affect how the other medications work. Before taking glyburide and metformin, tell your doctor about every medication and supplement that you are currently taking.

There are no foods you should specifically eat or avoid when taking glyburide and metformin, but you should be careful about alcoholic beverages, since glyburide and metformin can cause drowsiness and sometimes symptoms of hypoglycemia (low blood sugar). Drinking alcohol can make these effects worse. People who drink large amounts of alcohol, or who binge drink, should not take glyburide and metformin, because those habits can increase the risk of an extremely rare but life-threatening side effect of glyburide and metformin, called lactic acidosis.

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