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Are there any risks in taking Actos (pioglitazone)?

Yes, there are a number of risks in taking Actos. This drug may cause or worsen congestive heart failure. It may also cause liver disease. Women have a higher risk for getting pregnant while on this drug, as well as a higher risk for bone fractures. In clinical trials, it was discovered that those who take this drug are at increased risk for developing bladder cancer.