Why is there a black box warning for Viibryd?

The antidepressant Viibryd (vilazodone) carries a black box warning -- the most serious warning on a prescription drug label -- because studies have shown that Viibryd may increase risk of suicidal thoughts and behavior in children, teens and young adults under age 25.

Viibryd is one of several antidepressants that carry this warning. In studies of children treated with serotonin reuptake inhibitors (SSRIs), about 4% have suicidal thoughts or behaviors, including actual suicide attempts. This is about twice the rate seen in children who took placebos.

Researchers have concluded that, in some cases, the benefits of treating a child with major depressive disorder (MDD) with SSRIs outweighs the potential risks. However, the U.S. Food and Drug Administration (FDA) emphasizes that children and adolescents should be monitored closely while taking SSRIs.

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