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Why is there a black box warning on Nardil?

There is a black box warning on Nardil (phenelzine) because some research shows that it and other antidepressants may increase the risk of suicidal thoughts and attempts in children, teens and adults under age 25 who take it. A black box warning is the most serious caution used in drug labeling. Nardil is not approved by the Food and Drug Administration to treat mental illness in children, but in some circumstances a doctor might decide that it's the best treatment for a child or teen suffering from depression, anxiety or other conditions.

Whether Nardil is prescribed for you or your child, you and your doctor need to weigh Nardil's potential benefits against its potential risks. You should watch for signs of potential trouble, including worsening depression or anxiety, aggressive or reckless behavior, talk or actions concerning self-harm, trouble sleeping, extreme agitation, irritability, worry, impulsiveness, panic attacks, or frenzied or abnormal excitement, all of which may be symptoms of a potentially dangerous shift in mood.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.