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When should I call my doctor if I am taking Tofranil?

The antidepressant Tofranil (imipramine) may trigger a range of side effects that require medical attention. The most serious is a worsening of symptoms or the onset of suicidal thoughts. If you should experience either of those side effects or any of the following symptoms, call your doctor immediately:
  • extreme worry
  • agitation
  • panic attacks
  • difficulty falling asleep or staying asleep
  • aggressive behavior
  • irritability
  • acting without thinking
  • severe restlessness
  • frenzied abnormal excitement
Other possible side effects of Tofranil that you should call your doctor about immediately include:
  • jaw, neck and back spasms
  • slow or difficult speech
  • shuffling walk
  • uncontrollable shaking
  • fever
  • yellowing of your skin or eyes
  • an irregular heartbeat
  • eye pain, changes in vision or swelling or redness in the eye
You also should call your doctor if you develop any of these less serious side effects of Tofranil and they get worse or don't go away:
  • nausea
  • drowsiness
  • weakness or tiredness
  • excitement or anxiety
  • nightmares
  • dry mouth
  • extra sensitivity to the sun
  • changes in appetite or weight
  • constipation
  • difficulty urinating or urinating frequently
  • excessive sweating

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.