What are the possible side effects of Tofranil in children?

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Children who take Tofranil (imipramine) for depression may experience a range of side effects, the most serious being a risk of worsening symptoms or suicidal thoughts. For this reason, like all antidepressants Tofranil carries a black box warning.

If your child is taking Tofranil and experiences any of the following symptoms, call your doctor immediately:
  • extreme worry
  • agitation
  • panic attacks
  • trouble falling asleep or staying asleep
  • aggressive behavior
  • irritability
  • acting without thinking
  • severe restlessness
  • frenzied abnormal excitement
Other possible side effects for which you should call your child’s doctor immediately include:
  • jaw, neck and back spasms
  • slow or difficult speech
  • shuffling walk
  • uncontrollable shaking
  • fever
  • yellowing of the skin or eyes
  • irregular heartbeat
Side effects in children who take Tofranil for bedwetting tend to be less severe and often go away with continued treatment. The most common are nervousness, sleep disorders, tiredness and mild stomach upset.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.