What are the possible side effects of Tofranil?

A number of side effects are possible with the antidepressant Tofranil (imipramine). The most serious is a worsening of depression symptoms or the onset of suicidal thoughts. Although young adults under age 24 are especially at risk for these side effects, they can occur in anyone, especially at the beginning of treatment.

If you should experience either of those side effects or any of the following symptoms, call your doctor immediately:
  • extreme worry
  • agitation
  • panic attacks
  • difficulty falling asleep or staying asleep
  • aggressive behavior
  • irritability
  • acting without thinking
  • severe restlessness
  • frenzied abnormal excitement
It’s important to tell your family and friends about these potential side effects so they can help to keep an eye out for them and get help if you aren't able to.

Other possible side effects of Tofranil you should immediately call your doctor about include:
  • jaw, neck and back spasms
  • slow or difficult speech
  • shuffling walk
  • uncontrollable shaking
  • fever
  • yellowing of your skin or eyes
  • an irregular heartbeat
  • eye pain, changes in vision or swelling or redness in the eye
Tofranil can cause the following side effects. If you develop any of these and they get worse or don't go away, let your doctor know:
  • nausea
  • drowsiness
  • weakness or tiredness
  • excitement or anxiety
  • nightmares
  • dry mouth
  • extra sensitivity to the sun
  • changes in appetite or weight
  • constipation
  • difficulty urinating or urinating frequently
  • excessive sweating

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.