What are the possible side effects of Paxil CR?

Common possible side effects of the antidepressant Paxil CR (paroxetine) include:
  • nausea
  • constipation or diarrhea
  • drowsiness, trouble sleeping, yawning
  • weakness
  • dizziness
  • anxiety
  • sexual problems (low desire and/or trouble performing)
  • sweating
  • shaking
  • decreased appetite
  • dry mouth
Certain side effects of Paxil CR may be serious or even life threatening. Call your doctor if you experience any of the following:
  • changes in mood or behavior, such as acting impulsively, aggressively or violently; new or worse depression or anxiety; symptoms of mania (restlessness, agitation, fast talking, racing thoughts); suicidal thoughts or behavior
  • eye pain, changes in vision or swelling or redness in the eye
  • symptoms of serotonin syndrome (a condition in which the brain has too much of the chemical neurotransmitter serotonin), including hallucinations, agitation, racing heartbeat, high or low blood pressure, sweating or fever, vomiting or diarrhea, coordination problems, muscle stiffness or twitching
  • signs of allergic reaction including trouble breathing, hives or skin rash, fever, joint pain, swelling of the face, tongue, eyes or mouth
  • abnormal bleeding, especially if you also take blood thinners or nonsteroidal anti-inflammatory drugs, such as ibuprofen, naproxen or aspirin
  • seizures or convulsions
  • symptoms of low levels of sodium in the blood (more common in elderly people who take Paxil CR), including headache, weakness or feeling unsteady, confusion, trouble concentrating, memory problems
  • difficulty urinating or changes in frequency of urination
  • numbness, tingling, or burning pain in your hands, arms, feet or legs
Paxil CR may also interact with other medications, increasing your risk of side effects. Before taking Paxil CR, give your doctor a list of all your medicines (prescription and over-the-counter) and dietary and herbal supplements.

Your doctor will monitor you closely while you take Paxil CR, especially when you are starting treatment, to see how you respond to the drug.

Continue Learning about Antidepressant

Are Antidepressants Safe to Take During Pregnancy?
Are Antidepressants Safe to Take During Pregnancy?
Research suggests that depression is diagnosed twice as often in women as it is in men, and it typically presents during a woman’s childbearing years....
Read More
What are the most commonly prescribed antidepressants?
John Preston, PsyDJohn Preston, PsyD
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants...
More Answers
How effective is duloxetine for treating osteoarthritis?
Donna Hill Howes, RNDonna Hill Howes, RN
Research on duloxetine has found it to be about as effective as NSAIDs for improving pain and functi...
More Answers
What Is Treatment-Resistant Depression?
What Is Treatment-Resistant Depression?

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.