What medications and activities should I avoid while taking mirtazapine?

While taking mirtazapine you should avoid drinking alcohol, as it can increase certain side effects including dizziness. Medications such as allergy or cold medicine, along with several other over-the-counter and prescription medications, can interfere with mirtazapine and may need to be avoided.

Hydantoins and clonidine can make mirtazapine less effective, while fluvoxamine can increase its effects. Due to the risk of serotonin syndrome, mirtazapine should not be used in combination with MAO inhibitors or serotonin-precursors (such as oxitriptan and L-tryptophan). Mirtazapine also should be used with caution if you take serotonergic drugs (e.g., triptans, lithium, tramadol, St. John’s Wort and most tricyclic antidepressants).

Other medications may also interact with mirtazapine. Be sure to tell your doctor about all of the medications you take before starting mirtazapine.

If you have phenylketonuria, avoid mirtazapine disintegrating tablets, as the aspartame in these tablets can cause mental retardation if you have this condition.

Avoid driving or performing hazardous activities until you know how mirtazapine affects your alertness.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.